Global health review

MSF outreach workers test people for kala azar, Fulbaria, Mymensingh district, Bangladesh. Caption
MSF outreach workers test people for kala azar, Fulbaria, Mymensingh district, Bangladesh.

A weekly round-up of all the latest global health research from MSF projects and beyond

17 May 2024       

The MSF Scientific Days conference was yesterday, during which we enjoyed presentations on new regimens for multidrug-resistant tuberculosis, malaria early warning systems, and an improved personal protective equipment for infectious disease outbreaks. Check out the MSF Science Portal for all the posters and abstracts presented on the day.

This week, MSF and DNDi contribute to research in Transactions of the Royal Society of Tropical Medicine & Hygiene investigating the link between climate change and malaria and neglected tropical diseases. The Lancet Infectious Diseases assesses the diagnostic capabilities of the Pan-Lassa rapid diagnostic test for detecting Lassa fever in people in Nigeria. Nature Communications finds that sputum culture reversion was infrequent in patients with drug-resistant tuberculosis treated with longer-term regimens and repurposed drugs, but was associated with multiple factors such as weight, pulmonary cavities, hepatitis C, and certain prior medications.

Finally, BMC Health Services Research survey 140 Pakistani clinical specialists on the future role of AI in healthcare, finding that most had a positive attitude towards its use while acknowledging concerns about privacy and unemployment.  

 

Best regards

 

Mohammad Salaymeh, Lydia Lampiri, Ononna Thuli and Holly Baker with MSF-authored article assistance from Patricia Kahn and Camryn Lewis.

 

All MSF-authored publications can be found on the MSF Science Portal, as well as recordings, abstracts and posters from the MSF Scientific Days International 2023 conference.

 

Conflict, migration and health

The Lancet Planetary Health • Article: Placental DNA methylation signatures of prenatal air pollution exposure and potential effects on birth outcomes: an analysis of three prospective cohorts

The Lancet Global Health • Viewpoint: Short-term aid or long-term gains? Harnessing Sudan's humanitarian response for the resilience of its health system

Conflict and Health • Case Study: Strengthening event-based surveillance (EBS): a case study from Afghanistan

 

Global health

PLOS Global Public Health • Article: An exploratory study on becoming a traditional spiritual healer among Baganda in Central Uganda

The Lancet Global Health • Comment: Enhancing innovative training and education in infection prevention and control: a call to action for World Hand Hygiene Day 2024


PLOS Global Public Health • Article: From lemming to leader: Moving beyond Gross Domestic Product (GDP) to bring health financing assistance into the 21st century

The Lancet • Article: Preventing deaths after prison release

 

Infectious diseases

The Lancet Infectious Disease • Article: Association of nirmatrelvir–ritonavir with post-acute sequelae and mortality in patients admitted to hospital with COVID-19: a retrospective cohort study

Conflict and Health • Article: Did aid to the Ebola crisis divert aid for reproductive, maternal, and newborn health? An analysis of donor-reported data in Sierra Leone

The Lancet Infectious Disease • Comment: Early life respiratory syncytial virus disease—a preventable burden

The Lancet Infectious Disease • Comment: Oral antivirals for acute symptoms and post-acute sequelae in SARS-CoV-2 infection

The Lancet Infectious Disease • Article***EPICENTRE AUTHOR & MENTIONS MSF***: Reporting of deaths during cholera outbreaks: case fatality ratio and community deaths

The Lancet Infectious Disease • Article: Shifting transmission patterns of human mpox in South Kivu, DR Congo

 

Malaria

Malaria Journal • Article: Access to quality-assured artemisinin-based combination therapy and associated factors among clients of selected private drug outlets in Uganda

BugBitten • Article: Bioarcheologists investigate the origin of the malaria parasite infecting the Romans

Malaria Journal • Article: Exploring the role of spending on malaria incidence in Uganda using the auto-regressive distributed lag approach

The Lancet Infectious Disease • Article: Genotypic analysis of RTS,S/AS01E malaria vaccine efficacy against parasite infection as a function of dosage regimen and baseline malaria infection status in children aged 5–17 months in Ghana and Kenya: a longitudinal phase 2b randomised controlled trial

Malaria Journal • Article: Predictors of accessing seasonal malaria chemoprevention medicines through non-door-to-door distribution in Nigeria

Malaria Journal • Review: Repurposing of anti-malarial drugs for the treatment of tuberculosis: realistic strategy or fanciful dead end?

Malaria Journal • Article: Statistical design and analysis of controlled human malaria infection trials

 

Maternal and child health

PLOS Global Public Health • Article: A retrospective study of congenital anomalies and associated risk factors among children admitted at a tertiary hospital in northwestern Tanzania

The Lancet Child & Adolescent Health • Editorial: Eliminating hepatitis B: the ball is in our court

PLOS Global Public Health • Article: Prediction models for post-discharge mortality among under-five children with suspected sepsis in Uganda: A multicohort analysis

JAMA • Article: Racial and Ethnic Disparities in All-Cause and Cause-Specific Mortality Among US Youth

 

Mental health

PLOS Global Public Health • Article: Mental Health of Adolescents Exposed to the War in Ukraine

 

Neglected tropical diseases

TRSTMH • Article***MENTIONS MSF & DNDi***: Blood transfusion in the care of patients with visceral leishmaniasis: a review of practices in therapeutic efficacy studies

Comm. Bio. • Article***MENTIONS MSF***: Persistent T cell unresponsiveness associated with chronic visceral leishmaniasis in HIV-coinfected patients

PLOS Neglected Tropical Disease • Article: Small Intestine Bacterial Overgrowth is associated with increased Campylobacter and epithelial injury in duodenal biopsies of Bangladeshi children

 

Non-communicable diseases

eClinicalMedicine • Article: Cancer in prison: barriers and enablers to diagnosis and treatment

eClinicalMedicine • Article: Projecting the economic burden of chronic kidney disease at the patient level (Inside CKD): a microsimulation modelling study

PLOS Global Public Health • Article: Psychosocial impact of surgical complications and the coping mechanisms among surgeons in Uganda and Eastern Democratic Republic of the Cong

The Lancet Diabetes & Endocrinology • Article: Sex, race, and BMI in clinical trials of medications for obesity over the past three decades: a systematic review

 

Tuberculosis

eClinicalMedicine • Article***MENTIONS EPICENTRE***: Effect of decentralising childhood tuberculosis diagnosis to primary health centre versus district hospital levels on disease detection in children from six high tuberculosis incidence countries: an operational research, pre-post intervention study

Open Forum Infectious Diseases • Article***MSF AUTHOR***: Xpert-Ultra assay on stool and urine to improve tuberculosis diagnosis in children: the Médecins Sans Frontières experience in Guinea-Bissau and South Sudan

 

Vaccines

The Lancet • Article: Contribution of vaccination to improved survival and health: modelling 50 years of the Expanded Programme on Immunization

The Lancet • Comment***EPICENTRE AUTHOR & MENTIONS MSF***: Measles and rubella vaccine microneedle patch: new hope to reach the unreached children

 

Zika

PLOS Neglected Tropical Disease • Article: Biased virus transmission following sequential coinfection of Aedes aegypti with dengue and Zika viruses